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David Colcher Selected Research

Immunoglobulin Fragments

9/2017Synthesis, Positron Emission Tomography Imaging, and Therapy of Diabody Targeted Drug Lipid Nanoparticles in a Prostate Cancer Murine Model.
4/2017PET imaging of 64Cu-DOTA-scFv-anti-PSMA lipid nanoparticles (LNPs): Enhanced tumor targeting over anti-PSMA scFv or untargeted LNPs.
3/2013A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance.
2/2008Biodistribution and tumor imaging of an anti-CEA single-chain antibody-albumin fusion protein.
1/2007Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy.
9/2005Penetratin improves tumor retention of single-chain antibodies: a novel step toward optimization of radioimmunotherapy of solid tumors.
1/2005Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.
8/2004Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer.

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David Colcher Research Topics

Disease

41Neoplasms (Cancer)
01/2021 - 07/2002
3Ovarian Neoplasms (Ovarian Cancer)
01/2021 - 01/2018
3Colorectal Neoplasms (Colorectal Cancer)
09/2017 - 08/2004
3Adenocarcinoma
01/2015 - 07/2002
2Multiple Myeloma
10/2020 - 01/2018
2Brain Neoplasms (Brain Tumor)
10/2018 - 08/2006
2Glioblastoma (Glioblastoma Multiforme)
10/2018 - 08/2006
2Prostatic Neoplasms (Prostate Cancer)
09/2017 - 04/2017
2Lymphoma (Lymphomas)
05/2013 - 07/2009
2Breast Neoplasms (Breast Cancer)
08/2010 - 09/2005
2Glioma (Gliomas)
08/2006 - 04/2005
1Bacteremia
12/2021
1Hodgkin Disease (Hodgkin's Disease)
12/2021
1Cytopenia
02/2020
1Myeloid Leukemia (Leukemia, Myelocytic)
12/2019
1Ascites
01/2018
1Hematologic Neoplasms (Hematological Malignancy)
01/2018
1Mucositis
09/2017
1Neoplasm Metastasis (Metastasis)
09/2017
1Carcinoma (Carcinomatosis)
11/2013
1Insulinoma
08/2011

Drug/Important Bio-Agent (IBA)

11AntigensIBA
10/2018 - 12/2002
9AntibodiesIBA
01/2021 - 08/2004
8Immunoglobulin FragmentsIBA
09/2017 - 08/2004
8Monoclonal AntibodiesIBA
11/2013 - 03/2002
6Carcinoembryonic AntigenIBA
02/2020 - 05/2004
4Glycoproteins (Glycoprotein)IBA
01/2021 - 09/2005
4Pharmaceutical PreparationsIBA
09/2017 - 05/2013
41,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA
04/2017 - 07/2010
4Single-Chain AntibodiesIBA
09/2005 - 03/2003
4Peptides (Polypeptides)IBA
09/2005 - 07/2002
3Proteins (Proteins, Gene)FDA Link
01/2020 - 01/2007
3CytokinesIBA
10/2018 - 12/2008
3Chimeric Antigen ReceptorsIBA
10/2018 - 08/2011
3Sulfhydryl Compounds (Thiols)IBA
04/2017 - 01/2008
3PolymersIBA
04/2017 - 07/2009
3Immunoglobulin G (IgG)IBA
07/2010 - 03/2005
2Radioisotopes (Radionuclides)IBA
01/2021 - 07/2010
2Tumor Biomarkers (Tumor Markers)IBA
01/2021 - 09/2005
2daratumumabIBA
10/2020 - 01/2018
2GemcitabineFDA Link
02/2020 - 09/2017
2Interleukin-2 (IL2)IBA
01/2020 - 12/2008
2tumor-associated antigen 72IBA
01/2020 - 11/2013
2Membrane Proteins (Integral Membrane Proteins)IBA
01/2018 - 03/2002
2Lipid NanoparticlesIBA
09/2017 - 04/2017
2maleimideIBA
04/2017 - 11/2013
2Cysteine (L-Cysteine)FDA Link
04/2017 - 11/2013
2Indicators and Reagents (Reagents)IBA
11/2013 - 05/2004
2IT-101IBA
05/2013 - 07/2009
2CamptothecinIBA
05/2013 - 07/2009
2Biotin (Vitamin H)FDA Link
08/2011 - 03/2003
2IsotopesIBA
04/2011 - 04/2005
2Lysine (L-Lysine)FDA Link
04/2011 - 03/2005
2Trastuzumab (Herceptin)FDA Link
08/2010 - 09/2005
2Neoplasm Antigens (Tumor Antigens)IBA
12/2008 - 01/2006
2ChlorotoxinIBA
08/2006 - 04/2005
1Yttrium-90IBA
02/2020
1Indium-111IBA
02/2020
1Immunoconjugates (Immunoconjugate)IBA
01/2020
1A 17 (A-17)IBA
01/2020
1Cell Surface ReceptorsIBA
12/2019
1CopperIBA
01/2018
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2017
1auristatinIBA
09/2017
1Floxuridine (FUdR)FDA LinkGeneric
09/2017
1EstersIBA
04/2017
1LigandsIBA
04/2017
1MicellesIBA
04/2017
11,2-distearoylphosphatidylethanolamine (DSPE)IBA
04/2017
1AcidsIBA
11/2013
1Iodine-124IBA
11/2013
1Immunoglobulin Fab FragmentsIBA
11/2013
1Caspase 3 (Caspase-3)IBA
05/2013
1CyclodextrinsIBA
05/2013
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
05/2013
1Topoisomerase I InhibitorsIBA
05/2013
1Hematoxylin (Haematoxylon)IBA
05/2013
1Eosine Yellowish-(YS) (Eosin)IBA
05/2013
1Bispecific AntibodiesIBA
03/2013
1Exenatide (Byetta)FDA Link
08/2011
1EpitopesIBA
08/2011
1Cetuximab (Erbitux)FDA Link
08/2011
1ErbB Receptors (EGF Receptor)IBA
08/2010
1IndiumIBA
08/2010
1human ERBB2 proteinIBA
08/2010
12- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
07/2009
1trioctyl phosphine oxide (TOPO)IBA
07/2009
1Irinotecan (Camptosar)FDA LinkGeneric
07/2009
1DNA (Deoxyribonucleic Acid)IBA
07/2009
1AlbuminsIBA
02/2008

Therapy/Procedure

19Therapeutics
01/2021 - 03/2002
10Radioimmunotherapy
12/2021 - 07/2002
3Drug Therapy (Chemotherapy)
07/2009 - 08/2004
2Catheters
12/2021 - 08/2006
1Salvage Therapy
12/2021
1Cell Transplantation
12/2021
1Intravenous Injections
01/2015
1Microbubbles
01/2015
1Islets of Langerhans Transplantation
08/2011
1Microspheres (Microsphere)
08/2011